Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)

CLEC-2 is a member of new family of C-type lectin receptors characterized by a cytosolic YXXL downstream of three acidic amino acids in a sequence known as a hemITAM (hemi-immunoreceptor tyrosine-based activation motif). Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hughes, Craig E., Sinha, Uma, Pandey, Anjali, Eble, Johannes A., O'Callaghan, Christopher A., Watson, Steve P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576117/
https://ncbi.nlm.nih.gov/pubmed/23264619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411462
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados