Microdialysis Measurement of Intratumoral Temozolomide Concentration after Cediranib, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, in a U87 Glioma Model

BACKGROUND: Combining anti-angiogenesis agents with cytotoxic agents for the treatment of malignant gliomas, may affect the cytotoxic drug distribution by normalizing the blood brain-barrier (BBB). This study examines the intratumoral concentration of temozolomide (TMZ) in the presence and absence o...

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Bibliographic Details
Published in:Cancer Chemother Pharmacol
Main Authors: Grossman, Rachel, Tyler, Betty, Rudek, Michelle A., Kim, Eugene, Zadnik, Patti, Khan, Ursalan, Blakeley, Jaishri O., Pathak, Arvind P., Brem, Henry
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596243/
https://ncbi.nlm.nih.gov/pubmed/23649683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2172-3
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