DDIS-21. IN VITRO MICRODIALYSIS RECOVERY OF TRAMETINIB

BACKGROUND: Dysregulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase (PI3K) pathways is common in several primary brain tumors and metastatic cancers affecting the central nervous system. Trametinib, and oral MEK1/2 inhibitor, has been effective in preclinical studies agai...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Romo, Carlos, Anders, Nicole, Scardina, Morgan, Mukherjee, Debraj, Grossman, Stuart, O Blakeley, Jaishri, Rudek-Renaut, Michelle
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Drug Discovery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847899/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.272
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