Tissue-specific and reversible RNA interference in transgenic mice

Genetically engineered mice provide powerful tools for understanding mammalian gene function. These models traditionally rely on gene overexpression from transgenes or targeted, irreversible gene mutation. By adapting the tetracycline (tet)-responsive system previously used for gene overexpression,...

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Udgivet i:Nat Genet
Main Authors: Dickins, Ross A, McJunkin, Katherine, Hernando, Eva, Premsrirut, Prem K, Krizhanovsky, Valery, Burgess, Darren J, Yong Kim, Sang, Cordon-Cardo, Carlos, Zender, Lars, Hannon, Gregory J, Lowe, Scott W
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595852/
https://ncbi.nlm.nih.gov/pubmed/17572676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng2045
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