Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia-reperfusion

BACKGROUND: Cytochrome c (Cyt c) is a mobile component of the electron transport chain (ETC) which contains a tightly coordinated heme iron. In pathologic settings, a key ligand of the cyt c’s heme iron, methionine (Met(80)), is oxidized allowing cyt c to participate in reactions as a peroxidase wit...

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Библиографические подробности
Опубликовано в: :Biochim Biophys Acta
Главные авторы: Aluri, Hema S., Simpson, David C., Allegood, Jeremy C., Hu, Ying, Szczepanek, Karol, Gronert, Scott, Chen, Qun, Lesnefsky, Edward J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593697/
https://ncbi.nlm.nih.gov/pubmed/25092652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.07.017
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