A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusion

Background and Aims: AIF (apoptosis inducing factor) is a flavin and NADH containing protein located within mitochondria required for optimal function of the respiratory chain. AIF may function as an antioxidant within mitochondria, yet when released from mitochondria it activates caspase-independen...

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Autors principals: Chen, Qun, Szczepanek, Karol, Hu, Ying, Thompson, Jeremy, Lesnefsky, Edward J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106194/
https://ncbi.nlm.nih.gov/pubmed/25101006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00271
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