Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: Role of complex I inhibition vs. depolarization of inner mitochondrial membrane

BACKGROUND: The reverse electron flow-induced ROS generation (RFIR) is decreased in ischemia-damaged mitochondria. Cardiac ischemia leads to decreased complex I activity and depolarized inner mitochondrial membrane potential (ΔΨ) that are two key factors to affect the RFIR in isolated mitochondria....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Ross, Thomas, Szczepanek, Karol, Bowler, Elizabeth, Hu, Ying, Larner, Andrew, Lesnefsky, Edward J., Chen, Qun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380262/
https://ncbi.nlm.nih.gov/pubmed/23747300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.05.035
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados