Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: Role of complex I inhibition vs. depolarization of inner mitochondrial membrane

BACKGROUND: The reverse electron flow-induced ROS generation (RFIR) is decreased in ischemia-damaged mitochondria. Cardiac ischemia leads to decreased complex I activity and depolarized inner mitochondrial membrane potential (ΔΨ) that are two key factors to affect the RFIR in isolated mitochondria....

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Biochim Biophys Acta
Autors principals: Ross, Thomas, Szczepanek, Karol, Bowler, Elizabeth, Hu, Ying, Larner, Andrew, Lesnefsky, Edward J., Chen, Qun
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380262/
https://ncbi.nlm.nih.gov/pubmed/23747300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.05.035
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars