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Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia-reperfusion
BACKGROUND: Cytochrome c (Cyt c) is a mobile component of the electron transport chain (ETC) which contains a tightly coordinated heme iron. In pathologic settings, a key ligand of the cyt c’s heme iron, methionine (Met(80)), is oxidized allowing cyt c to participate in reactions as a peroxidase wit...
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Publicado no: | Biochim Biophys Acta |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593697/ https://ncbi.nlm.nih.gov/pubmed/25092652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.07.017 |
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