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Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization

The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulated in time and space and depends on guanine exchange factors (GEFs). However, the kinetics and subcellular localization of GEF activity towards RhoA are poorly defined. To study the mechanism underlyi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: van Unen, Jakobus, Reinhard, Nathalie R., Yin, Taofei, Wu, Yi I., Postma, Marten, Gadella, Theodorus W.J., Goedhart, Joachim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592971/
https://ncbi.nlm.nih.gov/pubmed/26435194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14693
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