Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization

The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulated in time and space and depends on guanine exchange factors (GEFs). However, the kinetics and subcellular localization of GEF activity towards RhoA are poorly defined. To study the mechanism underlyi...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: van Unen, Jakobus, Reinhard, Nathalie R., Yin, Taofei, Wu, Yi I., Postma, Marten, Gadella, Theodorus W.J., Goedhart, Joachim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592971/
https://ncbi.nlm.nih.gov/pubmed/26435194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14693
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