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The RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation
The BCR-ABL oncogene encodes an in-frame fusion protein containing NH(2)-terminal sequences derived from Bcr and COOH-terminal sequences derived from Abl. Bcr contains a centrally located RhoGEF domain that is retained within p210 Bcr-Abl. Although this domain is subject to autoinhibition in the con...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676674/ https://ncbi.nlm.nih.gov/pubmed/17922031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210841 |
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