High-Dose Sirolimus And Immune Selective Pentostatin Plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-Versus-Tumor Responses

PURPOSE: We hypothesized that lymphoid-selective host conditioning and subsequent adoptive transfer of sirolimus-resistant allogeneic T cells (T-Rapa), when combined with high-dose sirolimus drug therapy in vivo, would safely achieve anti-tumor effects while avoiding GVHD. EXPERIMENTAL DESIGN: Patie...

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Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Mossoba, Miriam E., Halverson, David C., Kurlander, Roger, Schuver, Bazetta Blacklock, Carpenter, Ashley, Hansen, Brenna, Steinberg, Seth M., Ali, Syed Abbas, Tageja, Nishant, Hakim, Frances T., Gea-Banacloche, Juan, Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Khuu, Hanh, Sabatini, Marianna, Stroncek, David, Levine, Bruce L., June, Carl H., Mariotti, Jacopo, Rixe, Olivier, Fojo, Antonio Tito, Bishop, Michael R., Gress, Ronald. E., Fowler, Daniel H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592398/
https://ncbi.nlm.nih.gov/pubmed/26071480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0340
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