Phase 2 clinical trial of rapamycin-resistant donor CD4(+) Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

In experimental models, ex vivo induced T-cell rapamycin resistance occurred independent of T helper 1 (Th1)/T helper 2 (Th2) differentiation and yielded allogeneic CD4(+) T cells of increased in vivo efficacy that facilitated engraftment and permitted graft-versus-tumor effects while minimizing gra...

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Detalhes bibliográficos
Main Authors: Fowler, Daniel H., Mossoba, Miriam E., Steinberg, Seth M., Halverson, David C., Stroncek, David, Khuu, Hahn M., Hakim, Frances T., Castiello, Luciano, Sabatino, Marianna, Leitman, Susan F., Mariotti, Jacopo, Gea-Banacloche, Juan C., Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Rowley, Scott, Goy, Andre, Donato, Michele, Korngold, Robert, Pecora, Andrew, Levine, Bruce L., June, Carl H., Gress, Ronald E., Bishop, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624934/
https://ncbi.nlm.nih.gov/pubmed/23426943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-446872
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