Phase 2 clinical trial of rapamycin-resistant donor CD4(+) Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

In experimental models, ex vivo induced T-cell rapamycin resistance occurred independent of T helper 1 (Th1)/T helper 2 (Th2) differentiation and yielded allogeneic CD4(+) T cells of increased in vivo efficacy that facilitated engraftment and permitted graft-versus-tumor effects while minimizing gra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fowler, Daniel H., Mossoba, Miriam E., Steinberg, Seth M., Halverson, David C., Stroncek, David, Khuu, Hahn M., Hakim, Frances T., Castiello, Luciano, Sabatino, Marianna, Leitman, Susan F., Mariotti, Jacopo, Gea-Banacloche, Juan C., Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Rowley, Scott, Goy, Andre, Donato, Michele, Korngold, Robert, Pecora, Andrew, Levine, Bruce L., June, Carl H., Gress, Ronald E., Bishop, Michael R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2013
Pynciau:
Clinical Trials and Observations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624934/
https://ncbi.nlm.nih.gov/pubmed/23426943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-446872
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