High-Dose Sirolimus And Immune Selective Pentostatin Plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-Versus-Tumor Responses

PURPOSE: We hypothesized that lymphoid-selective host conditioning and subsequent adoptive transfer of sirolimus-resistant allogeneic T cells (T-Rapa), when combined with high-dose sirolimus drug therapy in vivo, would safely achieve anti-tumor effects while avoiding GVHD. EXPERIMENTAL DESIGN: Patie...

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發表在:Clin Cancer Res
Main Authors: Mossoba, Miriam E., Halverson, David C., Kurlander, Roger, Schuver, Bazetta Blacklock, Carpenter, Ashley, Hansen, Brenna, Steinberg, Seth M., Ali, Syed Abbas, Tageja, Nishant, Hakim, Frances T., Gea-Banacloche, Juan, Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Khuu, Hanh, Sabatini, Marianna, Stroncek, David, Levine, Bruce L., June, Carl H., Mariotti, Jacopo, Rixe, Olivier, Fojo, Antonio Tito, Bishop, Michael R., Gress, Ronald. E., Fowler, Daniel H.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592398/
https://ncbi.nlm.nih.gov/pubmed/26071480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0340
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