High-Dose Sirolimus And Immune Selective Pentostatin Plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-Versus-Tumor Responses

PURPOSE: We hypothesized that lymphoid-selective host conditioning and subsequent adoptive transfer of sirolimus-resistant allogeneic T cells (T-Rapa), when combined with high-dose sirolimus drug therapy in vivo, would safely achieve anti-tumor effects while avoiding GVHD. EXPERIMENTAL DESIGN: Patie...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Mossoba, Miriam E., Halverson, David C., Kurlander, Roger, Schuver, Bazetta Blacklock, Carpenter, Ashley, Hansen, Brenna, Steinberg, Seth M., Ali, Syed Abbas, Tageja, Nishant, Hakim, Frances T., Gea-Banacloche, Juan, Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Khuu, Hanh, Sabatini, Marianna, Stroncek, David, Levine, Bruce L., June, Carl H., Mariotti, Jacopo, Rixe, Olivier, Fojo, Antonio Tito, Bishop, Michael R., Gress, Ronald. E., Fowler, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592398/
https://ncbi.nlm.nih.gov/pubmed/26071480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0340
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