Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts

PURPOSE: The success of immunotoxin therapy of cancer is limited by host production of neutralizing antibodies, which are directed toward the Pseudomonas exotoxin A (PE) component. In this proof-of-principle study using a well-established murine model, we hypothesized that a newly developed immune d...

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Autori principali: Mossoba, Miriam E., Onda, Masanori, Taylor, Justin, Massey, Paul R., Treadwell, Shirin, Sharon, Elad, Hassan, Raffit, Pastan, Ira, Fowler, Daniel H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107891/
https://ncbi.nlm.nih.gov/pubmed/21521777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0493
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