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An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin. Immunotoxin BL22 targets CD22 positive malignancies and is composed of an anti-CD22 Fv fused to a 38-kDa fragment of Pseudomonas exotoxin A (PE38). BL22 has produced many...

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Detalhes bibliográficos
Main Authors: Onda, Masanori, Beers, Richard, Xiang, Laiman, Nagata, Satoshi, Wang, Qing-cheng, Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516223/
https://ncbi.nlm.nih.gov/pubmed/18678888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804851105
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