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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

Many nonhuman proteins have useful pharmacological activities, but are infrequently effective in humans because of their high immunogenicity. A recombinant immunotoxin (HA22, CAT8015, moxetumomab pasudotox) composed of an anti-CD22 antibody variable fragment fused to PE38, a 38-kDa portion of Pseudo...

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主要な著者: Onda, Masanori, Beers, Richard, Xiang, Laiman, Lee, Byungkook, Weldon, John E., Kreitman, Robert J., Pastan, Ira
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078343/
https://ncbi.nlm.nih.gov/pubmed/21436054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102746108
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