Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent anticancer agents that have produced many complete remissions in leukemia, but immunogenicity limits the number of doses that can be given to p...

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Hlavní autoři: Mazor, Ronit, Eberle, Jaime A., Hu, Xiaobo, Vassall, Aaron N., Onda, Masanori, Beers, Richard, Lee, Elizabeth C., Kreitman, Robert J., Lee, Byungkook, Baker, David, King, Chris, Hassan, Raffit, Benhar, Itai, Pastan, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060717/
https://ncbi.nlm.nih.gov/pubmed/24799704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405153111
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