Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent anticancer agents that have produced many complete remissions in leukemia, but immunogenicity limits the number of doses that can be given to p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mazor, Ronit, Eberle, Jaime A., Hu, Xiaobo, Vassall, Aaron N., Onda, Masanori, Beers, Richard, Lee, Elizabeth C., Kreitman, Robert J., Lee, Byungkook, Baker, David, King, Chris, Hassan, Raffit, Benhar, Itai, Pastan, Ira
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2014
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060717/
https://ncbi.nlm.nih.gov/pubmed/24799704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405153111
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