Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent anticancer agents that have produced many complete remissions in leukemia, but immunogenicity limits the number of doses that can be given to p...

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Autors principals: Mazor, Ronit, Eberle, Jaime A., Hu, Xiaobo, Vassall, Aaron N., Onda, Masanori, Beers, Richard, Lee, Elizabeth C., Kreitman, Robert J., Lee, Byungkook, Baker, David, King, Chris, Hassan, Raffit, Benhar, Itai, Pastan, Ira
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060717/
https://ncbi.nlm.nih.gov/pubmed/24799704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405153111
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