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Immunogenicity of therapeutic recombinant immunotoxins
Recombinant Immunotoxins (RITs) are chimeric proteins designed to treat cancer. They are made up of an Fv or Fab that targets an antigen on a cancer cell fused to a 38 kDa portion of Pseudomonas exotoxin A (PE38). Because PE38 is a bacterial protein, it is highly immunogenic in patients with solid t...
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| Publicado no: | Immunol Rev |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758696/ https://ncbi.nlm.nih.gov/pubmed/26864110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12390 |
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