Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

Protein-based drugs are very active in treating cancer, but their efficacy can be limited by the formation of neutralizing antidrug antibodies (ADAs). Recombinant immunotoxins are proteins that are very effective in patients with leukemia, where immunity is suppressed, but induce ADAs, which comprom...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Mazor, Ronit, King, Emily M., Onda, Masanori, Cuburu, Nicolas, Addissie, Selamawit, Crown, Devorah, Liu, Xiu-Fen, Kishimoto, Takashi Kei, Pastan, Ira
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789939/
https://ncbi.nlm.nih.gov/pubmed/29311317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717063115
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