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Strategies to Reduce the Immunogenicity of Recombinant Immunotoxins
Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv that targets a cancer antigen and a fragment of a bacterial toxin that kills tumor cells. Because the toxin is a foreign protein, it is immunogenic. The clinical success of...
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| Veröffentlicht in: | Am J Pathol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Investigative Pathology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099333/ https://ncbi.nlm.nih.gov/pubmed/29870741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.04.016 |
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