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Strategies to Reduce the Immunogenicity of Recombinant Immunotoxins

Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv that targets a cancer antigen and a fragment of a bacterial toxin that kills tumor cells. Because the toxin is a foreign protein, it is immunogenic. The clinical success of...

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Detalles Bibliográficos
Publicado en:Am J Pathol
Main Authors: Mazor, Ronit, King, Emily M., Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099333/
https://ncbi.nlm.nih.gov/pubmed/29870741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.04.016
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