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Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin
Recombinant immunotoxins (RITs) are chimeric proteins being developed for cancer treatment. They are composed of an antibody fragment that targets a cancer antigen and a cytotoxic portion of Pseudomonas exotoxin A. They are effective for patients with hematologic malignancies with defective immunity...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5840006/ https://ncbi.nlm.nih.gov/pubmed/29431691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701430 |
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