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Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell. Pseudomonas exotoxin A (PE) is a potent toxin that is used for the killing moiety in many immunotoxins. Moxetumomab...

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Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Mazor, Ronit, Pastan, Ira
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7333791/
https://ncbi.nlm.nih.gov/pubmed/32695104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01261
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