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A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity
Recombinant immunotoxins (RITs) are anti-cancer agents that combine the Fv of an antibody against cancer cells with a protein toxin from bacteria or plants. Since RITs contain a non-human protein, immunogenicity can be an obstacle in their development. In this study, we have explored the hypothesis...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276307/ https://ncbi.nlm.nih.gov/pubmed/22101015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr053 |
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