The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result in both acute pain during treatment and chronic persistent pain in cancer survivors. The hypothesis tested was that paclitaxel produces these adverse effects at least in part by sensitizing transient receptor pot...

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Publicado no:J Neurosci
Main Authors: Li, Yan, Adamek, Pavel, Zhang, Haijun, Tatsui, Claudio Esteves, Rhines, Laurence D., Mrozkova, Petra, Li, Qin, Kosturakis, Alyssa K., Cassidy, Ryan M., Harrison, Daniel S., Cata, Juan P., Sapire, Kenneth, Zhang, Hongmei, Kennamer-Chapman, Ross M., Jawad, Abdul Basit, Ghetti, Andre, Yan, Jiusheng, Palecek, Jiri, Dougherty, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588613/
https://ncbi.nlm.nih.gov/pubmed/26424893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1956-15.2015
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