The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result in both acute pain during treatment and chronic persistent pain in cancer survivors. The hypothesis tested was that paclitaxel produces these adverse effects at least in part by sensitizing transient receptor pot...

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Vydáno v:J Neurosci
Hlavní autoři: Li, Yan, Adamek, Pavel, Zhang, Haijun, Tatsui, Claudio Esteves, Rhines, Laurence D., Mrozkova, Petra, Li, Qin, Kosturakis, Alyssa K., Cassidy, Ryan M., Harrison, Daniel S., Cata, Juan P., Sapire, Kenneth, Zhang, Hongmei, Kennamer-Chapman, Ross M., Jawad, Abdul Basit, Ghetti, Andre, Yan, Jiusheng, Palecek, Jiri, Dougherty, Patrick M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588613/
https://ncbi.nlm.nih.gov/pubmed/26424893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1956-15.2015
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