Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Baumgart, Joel P., Zhou, Zhen-Yu, Hara, Masato, Cook, Daniel C., Hoppa, Michael B., Ryan, Timothy A., Hemmings, Hugh C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/
https://ncbi.nlm.nih.gov/pubmed/26351670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112
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