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Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling
Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/ https://ncbi.nlm.nih.gov/pubmed/26351670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112 |
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