Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Baumgart, Joel P., Zhou, Zhen-Yu, Hara, Masato, Cook, Daniel C., Hoppa, Michael B., Ryan, Timothy A., Hemmings, Hugh C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/
https://ncbi.nlm.nih.gov/pubmed/26351670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112
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