Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Baumgart, Joel P., Zhou, Zhen-Yu, Hara, Masato, Cook, Daniel C., Hoppa, Michael B., Ryan, Timothy A., Hemmings, Hugh C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/
https://ncbi.nlm.nih.gov/pubmed/26351670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items