Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Baumgart, Joel P., Zhou, Zhen-Yu, Hara, Masato, Cook, Daniel C., Hoppa, Michael B., Ryan, Timothy A., Hemmings, Hugh C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/
https://ncbi.nlm.nih.gov/pubmed/26351670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112
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