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Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling
Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/ https://ncbi.nlm.nih.gov/pubmed/26351670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112 |
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