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α(2)-Adrenergic receptor and isoflurane modulation of presynaptic Ca(2+) influx and exocytosis in hippocampal neurons

BACKGROUND: Evidence indicates that the anesthetic-sparing effects of α(2)-adrenergic receptor (AR) agonists involve α(2A)-AR heteroreceptors on non-adrenergic neurons. Since volatile anesthetics inhibit neurotransmitter release by reducing synaptic vesicle (SV) exocytosis, we hypothesized that α(2)...

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Bibliografiset tiedot
Julkaisussa:Anesthesiology
Päätekijät: Hara, Masato, Zhou, Zhen-Yu, Hemmings, Hugh C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988866/
https://ncbi.nlm.nih.gov/pubmed/27337223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001213
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