Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones

BACKGROUND: P/Q- and N-type voltage-gated calcium channels (VGCC) are the principal subtypes mediating synaptic vesicle (SV) exocytosis. Both the degree of isoflurane inhibition of SV exocytosis and VGCC subtype expression vary between brain regions and neurotransmitter phenotype. We hypothesised th...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Koyanagi, Yuko, Torturo, Christina L., Cook, Daniel C., Zhou, Zhenyu, Hemmings, Hugh C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Neuroscience and Neuroanaesthesia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676046/
https://ncbi.nlm.nih.gov/pubmed/31056238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.03.029
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