Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca(2+) influx, not Ca(2+)-exocytosis coupling

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of pre...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Baumgart, Joel P., Zhou, Zhen-Yu, Hara, Masato, Cook, Daniel C., Hoppa, Michael B., Ryan, Timothy A., Hemmings, Hugh C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586856/
https://ncbi.nlm.nih.gov/pubmed/26351670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500525112
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