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Isoflurane Modulates Hippocampal CA1 Pyramidal Neuron Excitability by Inhibition of both Transient and Persistent Sodium Currents in Mice

BACKGROUND: Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. We hypothesized that inhibition of transient and persistent neuronal sodium currents by...

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Bibliografiset tiedot
Julkaisussa:Anesthesiology
Päätekijät: Zhao, Wenling, Zhang, Mingyue, Liu, Jin, Liang, Peng, Wang, Rurong, Hemmings, Hugh C., Zhou, Cheng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586485/
https://ncbi.nlm.nih.gov/pubmed/31166240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002753
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