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Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons

The antiepileptic drug phenytoin (PHT) is thought to reduce the excitability of neural tissue by stabilizing sodium channels (Na(V)) in inactivated states. It has been suggested the fast-inactivated state (I(F)) is the main target, although slow inactivation (I(S)) has also been implicated. Other st...

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Detalhes bibliográficos
Publicado no:J Neurophysiol
Main Authors: Zeng, Zhen, Hill-Yardin, Elisa L., Williams, David, O'Brien, Terence, Serelis, Andris, French, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144711/
https://ncbi.nlm.nih.gov/pubmed/27489371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.01060.2015
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