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Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons

The antiepileptic drug phenytoin (PHT) is thought to reduce the excitability of neural tissue by stabilizing sodium channels (Na(V)) in inactivated states. It has been suggested the fast-inactivated state (I(F)) is the main target, although slow inactivation (I(S)) has also been implicated. Other st...

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Dades bibliogràfiques
Publicat a:J Neurophysiol
Autors principals: Zeng, Zhen, Hill-Yardin, Elisa L., Williams, David, O'Brien, Terence, Serelis, Andris, French, Christopher R.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144711/
https://ncbi.nlm.nih.gov/pubmed/27489371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.01060.2015
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