Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain’s parenchyma and is a key histopathological hallmark of Alzheimer’s disease (AD). Work on transgenic mice that overexpress A suggests that elevated A levels in the brain are associated with aberrant epileptifo...

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Detalhes bibliográficos
Main Authors: Francesco eTamagnini, Janet eNovelia, Talitha L Kerrigan, Jon T Brown, Krasimira eTsaneva-Atanasova, Andrew D Randall
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-10-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
Hippocampus
Ageing
hyperexcitability
Capacitance
Membrane properties
firing frequency
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00372/full
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