Isoflurane Modulates Hippocampal CA1 Pyramidal Neuron Excitability by Inhibition of both Transient and Persistent Sodium Currents in Mice

BACKGROUND: Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. We hypothesized that inhibition of transient and persistent neuronal sodium currents by...

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Bibliografske podrobnosti
izdano v:Anesthesiology
Main Authors: Zhao, Wenling, Zhang, Mingyue, Liu, Jin, Liang, Peng, Wang, Rurong, Hemmings, Hugh C., Zhou, Cheng
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586485/
https://ncbi.nlm.nih.gov/pubmed/31166240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002753
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