Reconciling depressed Ca(2+) sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

Abnormalities in cardiomyocyte Ca(2+) handling contribute to impaired contractile function in heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid bilayers have indicated that RyRs from failing hearts are more active than those from healthy hearts. Here, we an...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Ruiz-Hurtado, Gema, Li, Linwei, Fernández-Velasco, María, Rueda, Angélica, Lefebvre, Florence, Wang, Yueyi, Mateo, Philippe, Cassan, Cécile, Gellen, Barnabas, Benitah, Jean Pierre, Gómez, Ana María
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586588/
https://ncbi.nlm.nih.gov/pubmed/26371209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511366
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