Increased Ca(2+) sensitivity of the ryanodine receptor mutant RyR2(R4496C) underlies catecholaminergic polymorphic ventricular tachycardia

Cardiac ryanodine receptor (RyR2) mutations are associated with autosomal dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), suggesting that alterations in Ca(2+) handling underlie this disease. Here we analyze the underlying Ca(2+) release defect that leads to arrhythmia in card...

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Detaylı Bibliyografya
Asıl Yazarlar: Fernández-Velasco, María, Rueda, Angélica, Rizzi, Nicoletta, Benitah, Jean-Pierre, Colombi, Barbara, Napolitano, Carlo, Priori, Silvia G., Richard, Sylvain, Gómez, Ana María
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Lippincott Williams & Wilkins 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796688/
https://ncbi.nlm.nih.gov/pubmed/19096022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177493
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