Increased Ca(2+) sensitivity of the ryanodine receptor mutant RyR2(R4496C) underlies catecholaminergic polymorphic ventricular tachycardia

Cardiac ryanodine receptor (RyR2) mutations are associated with autosomal dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), suggesting that alterations in Ca(2+) handling underlie this disease. Here we analyze the underlying Ca(2+) release defect that leads to arrhythmia in card...

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Detalhes bibliográficos
Main Authors: Fernández-Velasco, María, Rueda, Angélica, Rizzi, Nicoletta, Benitah, Jean-Pierre, Colombi, Barbara, Napolitano, Carlo, Priori, Silvia G., Richard, Sylvain, Gómez, Ana María
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796688/
https://ncbi.nlm.nih.gov/pubmed/19096022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177493
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