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Increased Ca(2+) sensitivity of the ryanodine receptor mutant RyR2(R4496C) underlies catecholaminergic polymorphic ventricular tachycardia
Cardiac ryanodine receptor (RyR2) mutations are associated with autosomal dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), suggesting that alterations in Ca(2+) handling underlie this disease. Here we analyze the underlying Ca(2+) release defect that leads to arrhythmia in card...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Lippincott Williams & Wilkins
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796688/ https://ncbi.nlm.nih.gov/pubmed/19096022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177493 |
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