Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs

RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal arrhythmic disorder caused by mutations in the type-2 ryanodine receptor (RyR2). Mutant RyR2 cause abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR), which is associated with the development of ar...

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Publicado no:Int J Cardiol
Main Authors: Li, Na, Wang, Qiongling, Sibrian-Vazquez, Martha, Klipp, Robert C., Reynolds, Julia O., Word, Tarah A., Scott, Larry, Salama, Guy, Strongin, Robert M., Abramson, Jonathan J., Wehrens, Xander H.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5164850/
https://ncbi.nlm.nih.gov/pubmed/27838126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2016.10.078
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