In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

RATIONALE: Autosomal-dominant mutations in ryanodine receptor type-2 (RYR2) are responsible for ~60% of all catecholaminergic polymorphic ventricular tachycardia (CPVT). Dysfunctional RyR2 subunits trigger inappropriate calcium leak from the tetrameric channel resulting in potentially lethal ventric...

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Detaylı Bibliyografya
Yayımlandı:Circ Res
Asıl Yazarlar: Pan, Xiaolu, Philippen, Leonne, Lahiri, Satadru K., Lee, Ciaran, Park, So Hyun, Word, Tarah A., Li, Na, Jarrett, Kelsey E., Gupta, Rajat, Reynolds, Julia O., Lin, Jean, Bao, Gang, Lagor, William R., Wehrens, Xander H.T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206886/
https://ncbi.nlm.nih.gov/pubmed/30355031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313369
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