Increased Ca(2+) sensitivity of the ryanodine receptor mutant RyR2(R4496C) underlies catecholaminergic polymorphic ventricular tachycardia

Cardiac ryanodine receptor (RyR2) mutations are associated with autosomal dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), suggesting that alterations in Ca(2+) handling underlie this disease. Here we analyze the underlying Ca(2+) release defect that leads to arrhythmia in card...

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Bibliografski detalji
Glavni autori: Fernández-Velasco, María, Rueda, Angélica, Rizzi, Nicoletta, Benitah, Jean-Pierre, Colombi, Barbara, Napolitano, Carlo, Priori, Silvia G., Richard, Sylvain, Gómez, Ana María
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796688/
https://ncbi.nlm.nih.gov/pubmed/19096022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177493
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