Reconciling depressed Ca(2+) sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes

Abnormalities in cardiomyocyte Ca(2+) handling contribute to impaired contractile function in heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid bilayers have indicated that RyRs from failing hearts are more active than those from healthy hearts. Here, we an...

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Bibliografski detalji
Izdano u:J Gen Physiol
Glavni autori: Ruiz-Hurtado, Gema, Li, Linwei, Fernández-Velasco, María, Rueda, Angélica, Lefebvre, Florence, Wang, Yueyi, Mateo, Philippe, Cassan, Cécile, Gellen, Barnabas, Benitah, Jean Pierre, Gómez, Ana María
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586588/
https://ncbi.nlm.nih.gov/pubmed/26371209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511366
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