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Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry
Werner syndrome is a disorder characterized by a premature aging phenotype. The disease is caused by mutations in the WRN gene which encodes a DNA helicase/exonuclease which is involved in multiple aspects of DNA metabolism. Current methods mostly rely on radiometric techniques to assess WRN exonucl...
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| Publicado en: | Mech Ageing Dev |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4586252/ https://ncbi.nlm.nih.gov/pubmed/22766507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.06.005 |
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