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Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics

Poly(ADP-ribosyl)ation is an essential posttranslational modification with the biopolymer poly(ADP-ribose) (PAR). The reaction is catalyzed by poly(ADP-ribose) polymerases (PARPs) and plays key roles in cellular physiology and stress response. PARP inhibitors are currently being tested in clinical c...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Martello, Rita, Mangerich, Aswin, Sass, Sabine, Dedon, Peter C., Bürkle, Alexander
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795969/
https://ncbi.nlm.nih.gov/pubmed/23631432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400170b
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