Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection important structural aspects of the mechanism of how these proteins assemble into pores remain unknown. Streptococcus pneumoniae is the world’s...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585913/
https://ncbi.nlm.nih.gov/pubmed/26403197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14352
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