Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection important structural aspects of the mechanism of how these proteins assemble into pores remain unknown. Streptococcus pneumoniae is the world’s...

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Udgivet i:Sci Rep
Main Authors: Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585913/
https://ncbi.nlm.nih.gov/pubmed/26403197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14352
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