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Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin

Streptococcus pneumoniae produces the pore-forming toxin pneumolysin (PLY), which is a member of the cholesterol-dependent cytolysin (CDC) family of toxins. The CDCs recognize and bind the 3β-hydroxyl group of cholesterol at the cell surface, which initiates membrane pore formation. The cholesterol...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wade, Kristin R., Hotze, Eileen M., Briles, David E., Tweten, Rodney K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154877/
https://ncbi.nlm.nih.gov/pubmed/25188225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004353
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